While many people use Sayana Press without any side effects at all, it can be helpful to know what possible side effects you may experience so you can address them and prepare for them. The side effects with Sayana Press are similar to other forms of birth control.

Common birth control side effects available at bedsider.org

The most common side effects for Sayana Press are listed below:

Irregular menstrual bleeding

Some women have irregular periods, such as spotting during the cycle or heavy or lighter periods. This side effect may be gone after the first 2 or 3 shots. For many women, the periods may eventually stop. This is completely normal and safe and does not mean you are pregnant. When you stop using Sayana Press your periods will return to normal in a few months after the last shot.

Weight change

Some women report that they may gain or lose about 2.2 kilograms (5 pounds) while using Sayana Press. Maintaining healthy eating and lifestyle habits should help minimize weight changes.


Some women experience headaches but you can care for this as you take care of a normal headache. Try taking OTC pain medicine like paracetamol, eating, or drinking more water to see if it helps.

Injection site

You may experience pain or tenderness at the site of injection. Do not rub the injection site. The pain should go away within a day or two.


If you have questions, check out our FAQ Section here.